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Ancient RNA from Late Pleistocene permafrost and historic canids shows transcriptome survival that is tissue-specific

Introduction

The current revolution into the sequencing of ancient biomolecules has permitted multiple levels of omic information—including genomic 1, epigenomic 2,3, metagenomic 4,5, and proteomic 6,7—to be gleaned from ancient and archaeological product. This wealth of evolutionary information just about all derives from either DNA or protein, biomolecules both usually considered to be somewhat more stable than RNA. This really is regrettable, because transcriptome information have actually the prospective to get into deeper levels of information than genome sequencing alone. Such as, these generally include assessments associated with the in vivo task for the genome and assessing other facets of ancient bio-assemblages, such as for example biotic colonisation/microbiomes 8, host–pathogen interactions 9, therefore the degree of postmortem movement that is molecular keeps and surrounding media 10.

Inspite of the dominance of DNA, in modern times a few research reports have started to explore whether or otherwise not RNA endures in archaeological substrates, especially in the context of plant materials. (more…)